Effective Cytochrome P450 (CYP) Inhibitors Isolated from Tarragon (Artemisia dracunculus)

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著者

    • HIROI Asako
    • Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
    • MIYAKAWA Nami
    • Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
    • YAKOU Emi
    • Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
    • SUGAYA Kouichi
    • Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
    • ONOSE Jun-ichi
    • Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture
    • ABE Naoki
    • Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture

抄録

Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, <i>Artemisia dracunculus</i>. Their structures were spectroscopically identified as 2<i>E</i>,4<i>E</i>-undeca-2,4-diene-8,10-diynoic acid isobutylamide (<b>1</b>) and 2<i>E</i>,4<i>E</i>-undeca-2,4-diene-8,10-diynoic acid piperidide (<b>2</b>). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC<sub>50</sub> values of 10.0 ± 1.3 µ<small>M</small> for compound <b>1</b> and 3.3 ± 0.2 µ<small>M</small> for compound <b>2</b>, and exhibited mechanism-based inhibition. This is the first reported isolation of effective CYP inhibitors from tarragon (<i>Artemisia dracunculus</i>) purchased from a Japanese market.

収録刊行物

  • Bioscience, biotechnology, and biochemistry

    Bioscience, biotechnology, and biochemistry 76(5), 1028-1031, 2012-05-23

    公益社団法人 日本農芸化学会

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各種コード

  • NII論文ID(NAID)
    10030753249
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    09168451
  • NDL 記事登録ID
    023682071
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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