Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared from <i>Caulerpa lentillifera</i>

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  • MAEDA Reiko
    Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • IDA Tomoaki
    Department of Biological Science, Graduate School of Science, Osaka Prefecture University Department of Biological Science, Graduate School of Science, Osaka Prefecture University
  • IHARA Hideshi
    Department of Biological Science, Graduate School of Science, Osaka Prefecture University Department of Biological Science, Graduate School of Science, Osaka Prefecture University
  • SAKAMOTO Tatsuji
    Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University

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  • Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared from Caulerpa lentillifera

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Abstract

β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells.

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