Identification and Biological Activities of Bryostatins from Japanese Bryozoan

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著者

    • UENO Sayo UENO Sayo
    • Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • MURAKAMI Akira
    • Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • TOKUDA Harukuni
    • Department of Complementary and Alternative Medicine Clinical R&D, Graduate School of Medical Science, Kanazawa University
    • SUZUKI Nobutaka
    • Department of Complementary and Alternative Medicine Clinical R&D, Graduate School of Medical Science, Kanazawa University
    • IRIE Kazuhiro
    • Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

抄録

Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins 4, 10, and 14 suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.

Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins <b>4</b>, <b>10</b>, and <b>14</b> suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.

収録刊行物

  • Bioscience, biotechnology, and biochemistry

    Bioscience, biotechnology, and biochemistry 76(5), 1041-1043, 2012-05-23

    公益社団法人 日本農芸化学会

参考文献:  27件中 1-27件 を表示

各種コード

  • NII論文ID(NAID)
    10030753324
  • NII書誌ID(NCID)
    AA10824164
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    09168451
  • NDL 記事登録ID
    023682099
  • NDL 請求記号
    Z53-G223
  • データ提供元
    CJP書誌  NDL  IR  J-STAGE 
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