Identification and Biological Activities of Bryostatins from Japanese Bryozoan

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Author(s)

    • UENO Sayo UENO Sayo
    • Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • MURAKAMI Akira
    • Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    • TOKUDA Harukuni
    • Department of Complementary and Alternative Medicine Clinical R&D, Graduate School of Medical Science, Kanazawa University
    • SUZUKI Nobutaka
    • Department of Complementary and Alternative Medicine Clinical R&D, Graduate School of Medical Science, Kanazawa University
    • IRIE Kazuhiro
    • Department of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University

Abstract

Six bryostatins were isolated from Japanese bryozoan by evaluating their binding to the C1B domain of protein kinase Cδ (PKCδ). Structure-activity studies of bryostatins <b>4</b>, <b>10</b>, and <b>14</b> suggested that the ester group at C20 was not necessary for binding to and activating PKCδ. These bryostatins showed significant anti-tumor-promoting activity in induction tests with the Epstein-Barr virus early antigen.

Journal

  • Bioscience, Biotechnology, and Biochemistry

    Bioscience, Biotechnology, and Biochemistry 76(5), 1041-1043, 2012-05-23

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  27

Codes

  • NII Article ID (NAID)
    10030753324
  • NII NACSIS-CAT ID (NCID)
    AA10824164
  • Text Lang
    ENG
  • Article Type
    NOT
  • ISSN
    09168451
  • NDL Article ID
    023682099
  • NDL Call No.
    Z53-G223
  • Data Source
    CJP  NDL  IR  J-STAGE 
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