Expression and Localization of NO Synthase Isoenzymes (iNOS and eNOS) in Development of the Rabbit Placenta

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著者

    • KHAN Hamayun KHAN Hamayun
    • Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University
    • HIYAMA Masato
    • Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University
    • TAKESHITA Ai
    • Laboratory of Laboratory Animal Science, Division of Veterinary Science Animal Science, Graduate School of Life and Environmental Science, Osaka Prefecture University
    • KISO Yasuo
    • Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University

抄録

Nitric oxide synthase (NOS) is a key regulator of angiogenesis and embryogenesis in the mammalian reproductive process. Here, we attempted to clarify the expression and localization of inducible and endothelial NOS (iNOS and eNOS) in the developing rabbit placenta. Real-time RT-PCR analysis indicated that iNOS mRNA was significantly upregulated till the complete development of the placenta (d18), and then significantly decreased at the end of fetal growth stage (d28) during successful pregnancy. The eNOS mRNA was also enhanced in the pregnant uteri and gradually decreased near the term of pregnancy. Western blot analysis also showed elevation of the iNOS and eNOS protein levels during the course of successful pregnancy till the functional maturation of the placenta (d18). Immunohistochemical study revealed distinct localizations of iNOS along the radial arteries and eNOS at the spiral arteries and arterial sinuses in the developing placenta. This may reflect that iNOS and eNOS participate in pregnancy success through placentation-specific vascular formation and by supporting adequate blood circulation in the rabbit placenta.

収録刊行物

  • The Journal of reproduction and development

    The Journal of reproduction and development 58(2), 231-236, 2012-04-01

    日本繁殖生物学会

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各種コード

  • NII論文ID(NAID)
    10030753963
  • NII書誌ID(NCID)
    AA10936678
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09168818
  • NDL 記事登録ID
    023602079
  • NDL 請求記号
    Z54-H305
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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