Anatomy: Quantitative expression and immunohistochemical detection of glucose transporters, GLUT1 and GLUT3 in the rabbit placenta during successful pregnancy

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  • KHAN Hamayun
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan
  • KUSAKABE Ken Takeshi
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan Laboratory of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753-8515, Japan
  • WAKITANI Shoichi
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan
  • HIYAMA Masato
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan
  • TAKESHITA Ai
    Laboratory of Laboratory Animal Science, Division of Veterinary Science Animal Science, Graduate School of Life and Environmental Science, Osaka Prefecture University, Osaka 598-8531, Japan
  • KISO Yasuo
    Laboratory of Basic Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan Laboratory of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753-8515, Japan

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タイトル別名
  • Expression and Localization of NO Synthase Isoenzymes (iNOS and eNOS) in Development of the Rabbit Placenta
  • Quantitative Expression and Immunohistochemical Detection of Glucose Transporters, GLUT1 and GLUT3 in the Rabbit Placenta during Successful Pregnancy

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Nitric oxide synthase (NOS) is a key regulator of angiogenesis and embryogenesis in the mammalian reproductive process. Here, we attempted to clarify the expression and localization of inducible and endothelial NOS (iNOS and eNOS) in the developing rabbit placenta. Real-time RT-PCR analysis indicated that iNOS mRNA was significantly upregulated till the complete development of the placenta (d18), and then significantly decreased at the end of fetal growth stage (d28) during successful pregnancy. The eNOS mRNA was also enhanced in the pregnant uteri and gradually decreased near the term of pregnancy. Western blot analysis also showed elevation of the iNOS and eNOS protein levels during the course of successful pregnancy till the functional maturation of the placenta (d18). Immunohistochemical study revealed distinct localizations of iNOS along the radial arteries and eNOS at the spiral arteries and arterial sinuses in the developing placenta. This may reflect that iNOS and eNOS participate in pregnancy success through placentation-specific vascular formation and by supporting adequate blood circulation in the rabbit placenta.

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