NMR-based Metabolomic Analysis of Human Bladder Cancer

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著者

    • CAO Ming
    • Department of Urologic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
    • ZHAO Liangcai
    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    • CHEN Haige
    • Department of Urologic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
    • XUE Wei
    • Department of Urologic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
    • LIN Donghai
    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences

抄録

Bladder cancer (BC) is one of the most common cancers and has a high mortality rate. However, both metabolite variations and metabolic pathways related to the pathogenic process of BC remain to be addressed, such results might contribute to early detection of the disease. <sup>1</sup>H nuclear magnetic resonance (NMR)-based metabolomics was applied to identify differences of serum metabolic profiles among BC, calculi patients and healthy subjects. Serum metabolic profiles of BC patients are distinctly different from those of calculi and healthy subjects. Compared with those from healthy subjects, serum samples from BC patients show decreased levels of isoleucine/leucine, tyrosine, lactate, glycine, citrate, as well as increased levels of lipids and glucose. The results reveal disturbed metabolic pathways of aromatic amino acids, glycolysis and citrate cycle, as well as lipogenesis metabolism in BC patients. Our work will be of potential benefit to understanding the pathogenic process of BC and will offer valuable information for noninvasive diagnosis of the disease.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 28(5), 451-456, 2012-05-10

    社団法人 日本分析化学会

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各種コード

  • NII論文ID(NAID)
    10030757322
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • データ提供元
    CJP書誌  J-STAGE 
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