Molecularly Imprinted Microspheres for Bisphenol A Prepared Using a Microfluidic Device
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- TAKANO Eri
- Graduate School of Engineering, Kobe University
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- TANAKA Fujimaru
- Graduate School of Engineering, Kobe University
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- OOYA Tooru
- Graduate School of Engineering, Kobe University
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- TAKEUCHI Toshifumi
- Graduate School of Engineering, Kobe University
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Abstract
Spherical molecularly imprinted polymer particles for bisphenol A (BPA-MIP) were easily prepared by using a Y-junction microfluidic device. The sizes of the obtained BPA-MIP particles were found to be 86 μm with a narrow size distribution. The binding characteristics were investigated by drawing a binding isotherm to estimate the binding constant and by switching the polarity of solvents to examine the feasibility of use as a medium for affinity chromatography. When dichloromethane was used as a solvent, BPA was strongly bound to the spherical BPA-MIP particles based on hydrogen bond formation; after switching the solvent to methanol, BPA was eluted quantitatively due to the weakening of the hydrogen bonding, suggesting that the spherical BPA-MIP particles can be applied to affinity-type solid-phase extraction for BPA. As the present method can provide a diverse range of spherical MIPs without tedious procedures, MIP-based affinity media will be able to be more readily used as pretreatment and/or purification for various fields.
Journal
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- Analytical Sciences
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Analytical Sciences 28 (5), 457-461, 2012
The Japan Society for Analytical Chemistry
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Keywords
Details 詳細情報について
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- CRID
- 1390001204262053248
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- NII Article ID
- 10030757358
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- NII Book ID
- AA10500785
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- COI
- 1:STN:280:DC%2BC38jgslylug%3D%3D
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- ISSN
- 13482246
- 09106340
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- NDL BIB ID
- 023613906
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- PubMed
- 22687924
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed