自己組織化単分子膜の電気化学的な脱離と再生医療への応用 Electrochemical Desorption of Self-assembled Monolayers and Its Application for Regenerative Medicine

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著者

    • 福田 淳二 FUKUDA Junji
    • 筑波大学大学院 数理物質科学研究科 Graduate School of Pure and Applied Sciences, University of Tsukuba

抄録

Regenerative medicine aims to regenerate damaged tissues and organs by replacing them with tissue substitutes grown and reconstructed in the laboratory. One of the potential methods for reconstructing well-organized tissues <i>in vitro</i> is the use of cellular building blocks, such as cell sheets and spheroids. The fabrication and manipulation of such building blocks rely on innovative strategies for noninvasive cleavage of cell-to-culture substrate connections while preserving cell-to-cell connections. Several examples toward this end including our electrochemical approach have been presented. In our approach, cells are cultured on self-assembled monolayers (SAMs) of alkanethiols or oligopeptides adsorbed on a gold surface. The SAM was then reductively desorbed from the gold substrate by the application of a negative electrical potential. This caused the cells to detach from the gold surface in a rapid and reliable manner while maintaining cell-cell connections. This technology can be used to fabricate cell sheets, spheroids, and vascular-like structures.

収録刊行物

  • 膜 37(3), 113-118, 2012-05-01

    日本膜学会

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各種コード

  • NII論文ID(NAID)
    10030759402
  • NII書誌ID(NCID)
    AN0023215X
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    03851036
  • NDL 記事登録ID
    023813155
  • NDL 請求記号
    Z18-1127
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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