Danhong Inhibits Oxidized Low-Density Lipoprotein–Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor γ–Mediated Pathway Danhong Inhibits Oxidized Low-Density Lipoprotein-Induced Immune Maturation of Dentritic Cells via a Peroxisome Proliferator Activated Receptor γ-Mediated Pathway

この論文にアクセスする

この論文をさがす

著者

抄録

Danhong injection (DHI), a Chinese Materia Medica standardized product extracted from <I>Radix Salviae miltiorrhizae</I> and <I>Flos Carthami tinctorii</I>, is effective in the treatment of atherosclerosis (AS)-related diseases. It is widely recognized that AS is a complex inflammatory disease of the arterial wall and the dendritic cells (DCs) is a major player in the pathogenesis of AS via mediating atherosclerotic antigen presenting and T lymphocytes. Here, we determined the effect and possible mechanism of DHI on oxidized low-density lipoprotein (ox-LDL)-induced maturation and immune function of DCs. Human monocyte-derived DCs were incubated with DHI or ciglitazone and were subsequently stimulated with ox-LDL to induce maturation. Similar to ciglitazone, a peroxisome proliferator activated receptor (PPAR) <I>γ</I> agonist, DHI, could significantly reduce ox-LDL-induced expressions of mature markers, enhance the endocytotic function, and inhibit secretions of cytokine on DCs. These effects of DHI could be partly reversed by silencing the PPAR<I>γ</I>. In conclusion, DHI could inhibit ox-LDL-induced maturation of DCs partly through activating a PPAR<I>γ</I>-mediated signaling pathway.

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 119(1), 1-9, 2012-05-20

    公益社団法人 日本薬理学会

参考文献:  32件中 1-32件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10030760100
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13478613
  • NDL 記事登録ID
    023634633
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ