Possible Modulation of the Amygdala on Metaplasticity Deficits in the Hippocampal CA1 Field in Early Postnatally Stressed Rats

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著者

    • YANAGAWA Yoshiki
    • Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
    • ISHIKAWA Shuhei
    • Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
    • KUBO Yasunori
    • Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
    • INOUE Sumitaka
    • Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido
    • YOSHIOKA Mitsuhiro
    • Department of Neuropharmacology, Hokkaido University Graduate School of Medicine
    • TOGASHI Hiroko
    • Department of Pharmacology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido

抄録

Several lines of evidence have shown that early life experiences have a profound impact on fear-related behavior, but the detailed mechanisms are unknown. The present study examined the possible involvement of the amygdala in behavioral deficits associated with fear memory in a juvenile stress model, with a focus on hippocampal synaptic function. Adult rats exposed to footshock (FS) stress during the second postnatal period (2wFS group) exhibited low levels of freezing in response to contextual fear conditioning (CFC). The CFC-induced suppression of long-term potentiation (LTP) in the CA1 field was not found in the 2wFS group. Additionally, synaptic metaplasticity, that is, low-frequency stimulation-induced suppression of subsequent LTP, did not occur in the 2wFS group; instead, LTP was induced. These synaptic changes mimicked the impairment in metaplasticity induced by reversible inactivation of the basolateral amygdala (BLA). Inactivation of the BLA markedly decreased freezing behavior in non-FS controls, similar to the 2wFS group. Furthermore, extracellular signal-regulated kinase activation in the BLA in response to CFC did not occur in the 2wFS group. These findings suggest that early postnatal stress may cause long-term dysfunction of the modulatory effect of the amygdala on hippocampal function associated with fear memory.

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 119(1), 64-72, 2012-05-20

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10030760346
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13478613
  • NDL 記事登録ID
    023634686
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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