Down-Regulation of Myosin Light Chain Kinase Expression in Vascular Smooth Muscle Cells Accelerates Cell Proliferation : Requirement of Its Actin-binding Domain for Reversion to Normal Rates

この論文にアクセスする

この論文をさがす

著者

抄録

Myosin light-chain kinase (MLCK) is a multi-domain protein with kinase and actin-binding domains, among others. Deficiency of MLCK expression in GBaSM-4 vascular smooth muscle cells enhanced cell proliferation rate and shortened cell doubling time. Transient transfection of the MLCK-deficient cells with cDNA constructs of either wild-type MLCK or its mutant lacking the kinase activity reverted the cell proliferation rate to that of wild-type cells, whereas that of MLCK lacking the actin-binding domain maintained cell proliferation at an elevated rate similar to the MLCK-deficient cells. Thus, the actin-binding domain of MLCK seems to play a role in regulating cell proliferation.

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 119(1), 91-96, 2012-05-20

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

各種コード

  • NII論文ID(NAID)
    10030760488
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13478613
  • NDL 記事登録ID
    023634756
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ