Effect of Spinally Administered Simvastatin on the Formalin-Induced Nociceptive Response in Mice

この論文にアクセスする

この論文をさがす

著者

    • Mutoh Junpei MUTOH Junpei
    • Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
    • ONO Hideki
    • Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
    • HISA Hiroaki
    • Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare

抄録

Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 – 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 <I>μ</I>mol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission.

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 119(1), 102-106, 2012-05-20

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

各種コード

  • NII論文ID(NAID)
    10030760520
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13478613
  • NDL 記事登録ID
    023634765
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ