Possible Modulation of Process Extension by N-Methyl-D-aspartate Receptor Expressed in Osteocytic MLO-Y4 Cells

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著者

    • Fujita Hiroyuki FUJITA Hiroyuki
    • Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology
    • Hinoi Eiichi HINOI Eiichi
    • Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology
    • Nakatani Eri [他] NAKATANI Eri
    • Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology
    • YAMAMOTO Tomomi
    • Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology
    • TAKARADA Takeshi
    • Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology
    • YONEDA Yukio
    • Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology

抄録

In contrast to osteoblasts, little attention has been paid to expression profiles of different glutamatergic signaling machineries in osteocytes, which are the most abundant cells with a possible role as a mechanical sensor in bone. Here, we show that <I>N</I>-methyl-D-aspartate receptor (NMDAR) is expressed by osteocytic cells in five-weeks-old mouse tibiae in vivo as well as by osteocytic MLO-Y4 cells in vitro. Sustained exposure to the NMDAR antagonist dizocilpine significantly increased the number of cells with processes in cultured MLO-Y4 cells. These results suggest that NMDAR would be expressed by osteocytes with an unidentified role in the process extension.

収録刊行物

  • Journal of pharmacological sciences

    Journal of pharmacological sciences 119(1), 112-116, 2012-05-20

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

各種コード

  • NII論文ID(NAID)
    10030760551
  • NII書誌ID(NCID)
    AA11806667
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13478613
  • NDL 記事登録ID
    023634779
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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