Clinical significance of measurement of serum sialyl lewis^x (slx) levels in advanced colorectal cancer patients

• NAITO Yoshihisa

  Department of Surgery, National Defense Medical College

• HASHIGUCHI Yojiro

  Department of Surgery, National Defense Medical College

• SHIKINA Atushi

  Department of Surgery, National Defense Medical College

• SHINTO Eiji

  Department of Surgery, National Defense Medical College

• UENO Hideki

  Department of Surgery, National Defense Medical College

• MOCHIZUKI Hidetaka

  Department of Surgery, National Defense Medical College

• YAMAMOTO Junji

  Department of Surgery, National Defense Medical College

• HASE Kazuo

  Department of Surgery, National Defense Medical College

Bibliographic Information

Other Title

• 進行大腸癌における術前血中sialyl Lewis<SUP>X</SUP>値測定の有用性に関する検討
• 進行大腸癌における術前血中sialyl Lewis[x]値測定の有用性に関する検討
• シンコウ ダイチョウガン ニ オケル ジュツゼン ケッチュウ sialyl Lewis[x]アタイ ソクテイ ノ ユウヨウセイ ニ カンスル ケントウ
• Clinical significance of measurement of serum sialyl lewisx (slx) levels in advanced colorectal cancer patients

Abstract

[Aim] In colorectal cancer patients, a high preoperative serum sialyl Lewis^X (SLX) level is associated with a stage of the advanced disease. This study was undertaken to determine the usefulness of measurements of serum SLX in comparison with those of CEA and CA19-9.<BR>[Method] A total of 543 patients, who underwent resection for advanced colorectal cancer in our hospital between 1994 and 2002, were enrolled in this study. They were divided into low and high groups for each tumor marker respectively, and compared for their correlations with the histological curability C (Cur C) and prognosis.<BR>[Results] The frequencies of Cur c were 41.2%, 19.8%, and 29.9% in high SLX, CEA, and CA19-9 groups, respectively, which were significantly higher than each low level group (p<0.0001). Multivariate logistic regression analysis revealed that these three tumor markers were independent predictive factors for Cur C. The frequencies of Cur C by the number of tumor markers showing a high level were 0.7%, 5.6%, 21%, and 74.1% in 0, one, two, and three tumor markers, respectively. It showed that the number of high tumor markers correlated with the progression of the stage (p<0.0001). The five-year disease-specific survival rates were 90.9%, 71.1%, 64.9%, and 17.4%, respectively (p<0.0001).<BR>[Conclusion] The measurement of serum SLX level in patients with advanced colorectal cancer enabled us to gain more accurate preoperative prediction of histological curability and prognosis compared to the measurements of only serum CEA and CA19-9.

Journal

• Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

  Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 73 (3), 521-526, 2012

  Japan Surgical Association

Keywords

• sialyl Lewis<SUP>X</SUP> (SLX)
• colorectal cancer

Details

• CRID: 1390282679827627776
• NII Article ID: 10030762013
• NII Book ID: AA11189709
• DOI: 10.3919/jjsa.73.521
• ISSN: 18825133
• ISSN: 13452843
• NDL BIB ID: 030738662
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030738662
• Web Site: https://www.jstage.jst.go.jp/article/jjsa/73/3/73_521/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012194119
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed