Classification, Mechanism and General Considerations Regarding Clinical Application of Antiarrhythmic Drugs

• SHIRAKAMI Maiko

  Department of Anesthesiology, Self-Defense Force Hanshin Hospital

• HAYASHI Yukio

  Department of Anesthesiology, Osaka University Hospital

Bibliographic Information

Other Title

• 抗不整脈薬の分類，作用機序と使用上の原則と留意点

Abstract

  Ion channels and β receptors are involved in the effect of antiarrhythmic drugs and Vaughan Williams classification is excellent and widely used. However, it has several limitations, because drug actions are more complex. A more realistic approach to antiarrhythmic drugs is provided by Sicilian Gambit. This new classification system is designed to explore the mechanism of arrhythmias, the vulnerable parameter of arrhythmias most susceptible to modification, the target affecting the vulnerable parameter and selection of a drug that is most effective against the target. Furthermore, this classification lists the side effects that antiarrhythmic drugs produce, including proarrhythmic action. Understanding this new classification system may provide useful information in the clinical application of drugs.

Journal

• THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA

  THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 32 (3), 428-437, 2012

  THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA

Keywords

• Vaughan Williams classification
• Sicilian Gambit

Details

• CRID: 1390001204760394880
• NII Article ID: 10030763363
• NII Book ID: AN00330159
• DOI: 10.2199/jjsca.32.428
• ISSN: 13499149
• ISSN: 02854945
• Web Site: https://search.jamas.or.jp/link/ui/2012241577
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed