Development of π-Acidic Metal-Catalyzed Reactions toward Construction of Multi-Substituted Heterocycles
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- Nakamura Itaru
- Graduate School of Science, Tohoku University
Bibliographic Information
- Other Title
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- 多置換ヘテロ環の構築を志向するπ酸性遷移金属触媒反応の開発
- タチカン ヘテロカン ノ コウチク オ シコウ スル pサンセイ センイ キンゾク ショクバイ ハンノウ ノ カイハツ
- Development of ^|^pi;-Acidic Metal-Catalyzed Reactions toward Construction of Multi-Substituted Heterocycles
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Abstract
π-Acidic metal-catalyzed cyclization reaction is one of the most efficient methods to construct highly elaborate molecular skeletons in a single operation under mild reaction conditions. These transformations often involve cleavage of σ bonds. Investigations into catalytic skeletal rearrangement have mainly utilized alkynylamines, alkynylalcohols, enynes, and propargylic esters as substrates. In this article, I report our recent findings on π-acidic metal-catalyzed reactions via cleavage of σ bonds between major elements in body, such as carbon, nitrogen, oxygen, and sulfur, producing multisubstituted heterocycles in an atom-efficient manner. That is, (a) catalytic carbon-heteroatom bond addition of ortho-alkynylphenyl ethers, -anilines, and -phenyl sulfides and (b) catalytic skeletal rearrangement of O-propargylic oximes.
Journal
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- Journal of Synthetic Organic Chemistry, Japan
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Journal of Synthetic Organic Chemistry, Japan 70 (6), 581-592, 2012
The Society of Synthetic Organic Chemistry, Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282680315565440
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- NII Article ID
- 10030765740
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- NII Book ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC38XovF2mtLY%3D
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- ISSN
- 18836526
- 00379980
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- NDL BIB ID
- 023824485
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed