Parental History and Lifestyle Behaviors in Relation to Mortality From Stroke Among Japanese Men and Women: The Japan Collaborative Cohort Study

• Eguchi Eri

  Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine

• Iso Hiroyasu

  Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine

• Wada Yasuhiko

  Department of Nutrition, University of Kochi Department of Nutrition, Kochi Women’s University

• Kikuchi Shogo

  Department of Public Health, Aichi Medical University School of Medicine Department of Public Health, Aichi Medical University School of Medicine

• Watanabe Yoshiyuki

  Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Sciences Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Sciences

• Tamakoshi Akiko

  Department of Public Health, Aichi Medical University School of Medicine Department of Public Health, Aichi Medical University School of Medicine

• Mori Mitsuru

• Sakauchi Fumio

• Motohashi Yutaka

• Tsuji Ichiro

• Nakamura Yosikazu

• Mikami Haruo

• Kurosawa Michiko

• Tanabe Naohito

• Tamakoshi Koji

• Wakai Kenji

• Tokudome Shinkan

• Suzuki Koji

• Hashimoto Shuji

• Kawamura Takashi

• Ozasa Kotaro

• Miki Tsuneharu

• Date Chigusa

• Sakata Kiyomi

• Kurozawa Yoichi

• Yoshimura Takesumi

• Fujino Yoshihisa

• Okamoto Naoyuki

• Shio Hideo

• Yamamoto Akio

• Ando Masahiko

• Hoshiyama Yoshiharu

• Shibata Akira

Abstract

Background: We assessed the impact of parental history of stroke on stroke mortality, as well as the effect modification between lifestyle and stroke mortality, among Japanese.<BR>Methods: In this community-based, prospective cohort study, 22 763 men and 30 928 women aged 40 to 79 years with no history of cardiovascular disease or cancer at baseline (1988–1990) were followed through 2008. We examined the association between parental history of stroke and stroke mortality and estimated the impact of the combination of lifestyle and parental history on stroke mortality in offspring.<BR>Results: During a mean follow-up period of 15.9 years, there were 1502 stroke deaths. In both sexes, participants with a parental history of stroke had a higher risk of stroke mortality as compared with those without such a history. The respective multivariable hazard ratio (95% CI) and population attributable fraction were 1.28 (1.10–1.49) and 5.4% in men, 1.22 (1.04–1.43) and 4.3% in women, and 1.25 (1.12–1.40) and 4.8% in all participants, for offspring with a maternal and/or paternal history of stroke. There was an inverse association between healthy-lifestyle score and stroke mortality, irrespective of parental history of stroke. The overall multivariable hazard ratio for the highest (6–8) versus the lowest (0–3) score categories was 0.56 (95% CI, 0.43–0.72) for participants with a maternal and/or paternal history of stroke and 0.44 (0.36–0.53) for those without such a history.<BR>Conclusions: Parental history of stroke was associated with stroke mortality in offspring. The inverse association between healthy lifestyle behaviors and stroke mortality, regardless of parental history, suggests that lifestyle modification is beneficial, even among individuals with a parental history of stroke.

Journal

• Journal of Epidemiology

  Journal of Epidemiology 22 (4), 331-339, 2012

  Japan Epidemiological Association

Keywords

• parental history
• stroke
• lifestyle
• cohort study

Details

• CRID: 1390282679452900224
• NII Article ID: 10030784223
• NII Book ID: AA10952696
• DOI: 10.2188/jea.je20110163
• COI: 1:STN:280:DC%2BC38jps1ersg%3D%3D
• ISSN: 13499092
• ISSN: 09175040
• PubMed: 22790788
• Web Site: https://www.jstage.jst.go.jp/article/jea/22/4/22_JE20110163/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013173828
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed