A Case of Propranolol Therapy for Infantile Capillary Hemangiomas of the Parotis

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  • Hirahara Shinya
    Department of Otorhinolaryngology, Head and Neck Surgery Faculty of medicine, University of Miyazaki
  • Matsuda Keiji
    Department of Otorhinolaryngology, Head and Neck Surgery Faculty of medicine, University of Miyazaki
  • Toyama Katsuhiro
    Department of Otorhinolaryngology, Head and Neck Surgery Faculty of medicine, University of Miyazaki
  • Nagano Yuki
    Department of Otorhinolaryngology, Head and Neck Surgery Faculty of medicine, University of Miyazaki
  • Nagai Noriaki
    Department of Otorhinolaryngology, Head and Neck Surgery Faculty of medicine, University of Miyazaki
  • Tono Tetsuya
    Department of Otorhinolaryngology, Head and Neck Surgery Faculty of medicine, University of Miyazaki

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Other Title
  • Propranololが著効した乳幼児耳下腺血管腫の1例
  • 症例報告 Propranololが著効した乳幼児耳下腺血管腫の1例
  • ショウレイ ホウコク Propranolol ガ チョコウシタ ニュウヨウジ ジカセン ケッカン シュ ノ 1レイ

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Abstract

A 4-month-old healthy female infant presented with rapid onset of subaural swelling over a three-month period. A head and neck exam demonstrated a subaural elastic hard mass with a red birthmark below the left auricle. MRI of the neck demonstrated a well-defined parotid mass consistent with a haemangioma. We treated this infant with 1mg/kg of propranolol, which was gradually increased over two months to a dose of 2mg/kg daily. The tumor began to reduce in size within three days after drug administration, and became less prominent in one month, and had almost totally disappeared within four months. On ten-month follow-up, the patient was asymptomatic and repeated MRI demonstrated further regression of the tumor. Propranolol could be the first-line choice for treating haemangioma rather than simple observation, steroids, or invasive methods such as laser irradiation and sclerotherapy.

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