Strategy for personalized treatment of human papillomavirus-positive oropharyngeal squamous cell carcinoma

• Mizumachi Takatsugu

  Department of Otolaryngology- Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Hatakeyama Hiromitsu

  Department of Otolaryngology- Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Kano Satoshi

  Department of Otolaryngology- Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Sakashita Tomohiro

  Department of Otolaryngology- Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Suzuki Seigo

  Department of Otolaryngology- Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Homma Akihiro

  Department of Otolaryngology- Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Oridate Nobuhiko

  Department of Otolaryngology- Head and Neck Surgery, Hokkaido University Graduate School of Medicine

• Fukuda Satoshi

  Department of Otolaryngology- Head and Neck Surgery, Hokkaido University Graduate School of Medicine

Bibliographic Information

Other Title

• ＨＰＶ陽性中咽頭癌に対する個別化治療戦略

Abstract

We performed a retrospective analysis of the association between tumor HPV status and the demographic and clinicopathological parameters of 83 patients with oropharyngeal squamous cell carcinoma at Hokkaido University Hospital, Japan, between 1998 and 2010. The parameters included age, gender, tumor subsite, Tumor-Node-Metastasis (TNM) stage, and overall survival. HPV status was established by multiplex polymerase chain reaction analysis.<br>Of the 83 oropharyngeal cancers, 22 were positive for HPV-16, two for HPV-18, and one for HPV-35 and HPV-58. Kaplan-Meier survival analysis showed improved overall survival rates in patients with HPV-positive tumors (p = 0.0024) compared with HPV-negative tumors. Of the 51 patients who received chemoradiotherapy, HPV-positive patients experienced better overall survival than HPV-negative patients (p = 0.0024).<br>HPV status is a significantly favorable prognostic factor in oropharyngeal cancer in Japan.

Journal

• Toukeibu Gan

  Toukeibu Gan 37 (3), 394-397, 2011

  Japan Society for Head and Neck Cancer

Keywords

• Head and neck cancer
• Oropharyngeal cancer
• Human papillomavirus
• Chemoradiotherapy

Details

• CRID: 1390001205222461696
• NII Article ID: 130004510103
• NII Article ID: 10030815250
• NII Book ID: AA11985555
• DOI: 10.5981/jjhnc.37.394
• ISSN: 18818382
• ISSN: 13495747
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed