Integration of metabolic and cardiovascular diurnal rhythms by circadian clock

DOI Web Site PubMed 被引用文献2件 参考文献136件
  • Kohsaka Akira
    Department of Physiology, Wakayama Medical University School of Medicine, Wakayama 641-8509, Japan
  • Waki Hidefumi
    Department of Physiology, Wakayama Medical University School of Medicine, Wakayama 641-8509, Japan
  • Cui He
    Department of Physiology, Shandong Medical College, Shandong 250002, China
  • Gouraud Sabine S.
    Department of Physiology, Wakayama Medical University School of Medicine, Wakayama 641-8509, Japan
  • Maeda Masanobu
    Department of Physiology, Wakayama Medical University School of Medicine, Wakayama 641-8509, Japan

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Understanding how the 24-hour blood-pressure rhythm is programmed has been one of the most challenging questions in cardiovascular research. The 24-hour blood-pressure rhythm is primarily driven by the circadian clock system, in which the master circadian pacemaker within the suprachiasmatic nuclei of the hypothalamus is first entrained to the light/dark cycle and then transmits synchronizing signals to the peripheral clocks common to most tissues, including the heart and blood vessels. However, the circadian system is more complex than this basic hierarchical structure, as indicated by the discovery that peripheral clocks are either influenced to some degree or fully driven by temporal changes in energy homeostasis, independent of the light entrainment pathway. Through various comparative genomic approaches and through studies exploiting mouse genetics and transgenics, we now appreciate that cardiovascular tissues possess a large number of metabolic genes whose expression cycle and reciprocally affect the transcriptional control of major circadian clock genes. These findings indicate that metabolic cycles can directly or indirectly affect the diurnal rhythm of cardiovascular function. Here, we discuss a framework for understanding how the 24-hour blood-pressure rhythm is driven by the circadian system that integrates cardiovascular and metabolic function.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 59 (6), 447-456, 2012

    一般社団法人 日本内分泌学会

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