Loss of poly-γ-glutamic acid synthesis of Bacillus subtilis (natto) due to IS4Bsu1 translocation to swrA gene

  • KIMURA Keitarou
    Division of Applied Microbiology, National Food Research Institute
  • TRAN Lam-Son Phan
    RIKEN Plant Science Center, Gene Discovery Research Group Signaling Pathway Research Unit
  • FUNANE Kazumi
    Division of Applied Microbiology, National Food Research Institute

書誌事項

タイトル別名
  • Loss of poly-.GAMMA.-glutamic Acid Synthesis of Bacillus subtilis (natto) Due to IS4Bsu1 Translocation to swrA Gene

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The mobile genetic element IS4Bsu1 of Bacillus subtilis (natto), the commercial strain used for natto fermentation, was found to spontaneously translocate to the swrA gene, which led to a defect in poly-γ-glutamic acid (γPGA) synthesis. The γPGA defect of NAFIS1 (swrA::IS4Bsu1) was restored by a plasmid harboring the swrA gene. The insertion of IS4Bsu1 to the swrA gene appeared not to interfere with minJ gene expression, located downstream of the swrA gene, because a defect in cell motility exhibited by NAF16 (minJ::Spcr) was not observed in NAFIS1 (swrA::IS4Bsu1). We found that the minJ gene is essential for γPGA synthesis.

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詳細情報

  • CRID
    1390282679434351488
  • NII論文ID
    10030897158
  • NII書誌ID
    AA11320122
  • DOI
    10.3136/fstr.17.447
  • COI
    1:CAS:528:DC%2BC3MXhsVymurnO
  • ISSN
    18813984
    13446606
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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