NON-ANTIBIOTIC TREATMENT FOR PEDIATRIC OUTPATIENTS WITH COMMON COLD INHIBITS THE EMERGENCE OF DRUG RESISTANT PNEUMOCOCCI

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The occurrence of drug resistant Streptococcus pneurmoniae (S. pneumoniae) is very high in Japan. Unnecessary use of antibiotics had been thought to cause this problem but previous studies had not clearly showed that the decreasing rate of antibiotic use had been related to the reduction of the prevalence of resistant strains. In this study, we tried to prove that non-antibiotic treatment for common cold would reduce the antibiotic resistant S. pneumoniae in nasopharynx in children. Forty-five children with the common cold were randomly selected from pediatric patients who had taken antibiotics within the past three months. We collected nasopharyngeal swabs from all of the participants and once again after a period of 2 to 3 months without using any antibiotics. Twenty-four of these patients had the S. pneumoniae strains isolated. Then these strains were undergone a susceptibility test and drug-resistant gene detection. The susceptibility test reveled that patients with penicillin-resistant strains decreased from 17 to 7 (p < 0.01). The test also reveled that the decreased number of patients had strains that were resistant to cefditren. The gene detection revealed that none of the patients acquired a higher resistance to penicillin. Our study suggests that the treatment without antibiotics reduces the drug-resistant S. pneumoniae. Controlled antibiotic use in children might prevent children from carrying the antibiotic resistant S. pneumoniae.

The occurrence of drug resistant <i>Streptococcus pneumoniae (S. pneumoniae)</i> is very high in Japan. Unnecessary use of antibiotics had been thought to cause this problem but previous studies had not clearly showed that the decreasing rate of antibiotic use had been related to the reduction of the prevalence of resistant strains. In this study, we tried to prove that non-antibiotic treatment for common cold would reduce the antibiotic resistant <i>S. pneumoniae</i> in nasopharynx in children. Forty-five children with the common cold were randomly selected from pediatric patients who had taken antibiotics </i>within the past three months. We collected nasopharyngeal swabs from all of the participants and once again after a period of 2 to 3 months without using any antibiotics. Twenty-four of these patients had the <i>S. pneumoniae</i> strains isolated. Then these strains were undergone a susceptibility test and drug-resistant gene detection. The susceptibility test reveled that patients with penicillin-resistant strains decreased from 17 to 7 (<i>p</i>< 0.01). The test also reveled that the decreased number of patients had strains that were resistant to cefditren. The gene detection revealed that none of the patients acquired a higher resistance to penicillin. Our study suggests that the treatment without antibiotics reduces the drug-resistant <i>S. pneumoniae</i>. Controlled antibiotic use in children might prevent children from carrying the antibiotic resistant <i>S. pneumoniae</i>.

収録刊行物

  • Fukushima journal of medical science

    Fukushima journal of medical science 56(1), 28-37, 2010-06-01

    福島医学会

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各種コード

  • NII論文ID(NAID)
    10030916070
  • NII書誌ID(NCID)
    AA0065246X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00162590
  • データ提供元
    CJP書誌  IR  J-STAGE 
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