New Structure Descriptor in the Structure-Activity Relationship Study on the Suppression of Aryl Hydrocarbon Receptor Transformation by Anthraquinones

• KAWASE Masaya

  Faculty of Bioscience, Nagahama Institute of Bio-science and Technology

• SAITO Tadashi

  Radioisotope Research Center, Osaka University

• YASUNAGA Teruo

  Genome Information Research Center, Osaka University

• TAKAGI Tatsuya

  Graduate School of Pharmaceutical Sciences, Osaka University

• FUKUDA Itsuko

  Graduate School of Agricultural Science, Kobe University

• ASHIDA Hitoshi

  Graduate School of Agricultural Science, Kobe University

抄録

A new descriptor showing the positions of functional groups in compounds with the same main backbone was developed. This descriptor was applied to the Quantitative Structure-Activity Relationship (QSAR) study on the suppression activities of anthraquinones via transformation of the aryl hydrogen receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin. It was shown that the newly developed descriptor played an important role in the QSAR study.

収録刊行物

• Food Science and Technology Research

  Food Science and Technology Research 18 (2), 173-176, 2012

  公益社団法人 日本食品科学工学会

キーワード

• QSAR
• new descriptor
• anthraquinones
• aryl hydrocarbon receptor
• 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin
• hepatocytes

詳細情報

• CRID: 1390001204457321344
• NII論文ID: 10030917782
• NII書誌ID: AA11320122
• DOI: 10.3136/fstr.18.173
• COI: 1:CAS:528:DC%2BC38Xos1Oku7s%3D
• ISSN: 18813984
• ISSN: 13446606
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可