Preparation and Characterization of <i>N</i>-vinyl-2-pyrroridone-methyl Methacrylate-Methacrylic Acid Terpolymer-Coated Magnetite Nanoparticles

• YAMASHIRO Mai

  College of Bioscience and Biotechnology, Chubu University

• SUGIMURA Toshihide

  College of Bioscience and Biotechnology, Chubu University

• KOBAYASHI Takeshi

  Research Institute for Biological Function, Chubu University

• TSUTSUMIUCHI Kaname

  College of Bioscience and Biotechnology, Chubu University

Bibliographic Information

Other Title

• <i>N</i>-ビニル-2-ピロリドン/メタクリル酸メチル/メタクリル酸三元共重合体被覆マグネタイトナノ粒子の調製と特性解析
• N-ビニル-2-ピロリドン/メタクリル酸メチル/メタクリル酸三元共重合体被覆マグネタイトナノ粒子の調製と特性解析
• N-ビニル-2-ピロリドン/メタクリルサン メチル/メタクリルサン サンゲン キョウ ジュウゴウタイ ヒフク マグネタイトナノ リュウシ ノ チョウセイ ト トクセイ カイセキ
• Preparation and Characterization of N-vinyl-2-pyrroridone-methyl Methacrylate-Methacrylic Acid Terpolymer-Coated Magnetite Nanoparticles

Abstract

In this study, we synthesized N-vinyl-2-pyrrolidone-methyl methacrylate-methacrylic acid terpolymer sodium salt [P(VP-MMA-MA), 7] by reversible addition-fragmentation chain transfer polymerization of N-vinyl-2-pyrrolidone and methyl methacrylate followed by hydrolysis in 0.10 mol/L NaOH aqueous solution. Magnetite nanoparticles that were coated with 7 [P(VP-MMA-MA)-MNPs, 8] were prepared by thermal decomposition of iron pentacarbonyl in the presence of 7 in DMF under reflux. The iron concentration of 8 were 1.0–8.7 wt% in dry weight of nanoparticles. P(VP-MMA-MA)-MNPs solutions remained stable for several months without noticeable precipitation. TEM images of 8 showed that the average size of magnetite core were 10–20 nm. DLS measurements revealed that hydrodynamic diameter of 8 were 200–270 nm in phosphate buffered saline. MTT assay on macrophage cell line RAW 264.7 indicated neglectable cytotoxicity of 7 and 8. Finally, we confirmed that 8 generated heat in an alternating magnetic field. This study suggests that P(VP-MMA-MA)-MNPs are useful materials for MRI contrast enhancement and hyperthermia treatments.

Journal

• KOBUNSHI RONBUNSHU

  KOBUNSHI RONBUNSHU 69 (7), 392-398, 2012

  The Society of Polymer Science, Japan

Keywords

• Polyvinylpyrrolidone
• Magnetite
• Nanoparticle
• Magnetic Resonance Imaging (MRI)

Details

• CRID: 1390001206526593024
• NII Article ID: 10030932362
• NII Book ID: AN00085011
• DOI: 10.1295/koron.69.392
• COI: 1:CAS:528:DC%2BC38XhtFegs7nO
• ISSN: 18815685
• ISSN: 03862186
• NDL BIB ID: 023905761
• Web Site: http://id.ndl.go.jp/bib/023905761
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023905761
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed