Emodin, a Naturally Occurring Anthraquinone, Ameliorates Experimental Autoimmune Myocarditis in Rats

この論文にアクセスする

この論文をさがす

著者

    • SONG Zhan-Chun
    • Department of Cardiology, The First Hospital of China Medical University, China Medical University
    • WANG Zhan-Sheng
    • Department of Cardiology, The First Hospital of China Medical University, China Medical University
    • BAI Jing-Hui
    • Department of Cardiology, The First Hospital of China Medical University, China Medical University
    • LI Zhao
    • Department of Cardiology, The First Hospital of China Medical University, China Medical University
    • HU Jian
    • Department of Cardiology, The First Hospital of China Medical University, China Medical University

抄録

Myocarditis is an inflammatory disease of the heart and a major cause of dilated cardiomyopathy that can lead to heart failure and sudden death in young adults. Giant cell myocarditis is a severe heart disease of unknown causes and is defined histopathologically as diffuse myocardial necrosis with multinucleated giant cells in the absence of sarcoid-like granulomata. Giant cell myocarditis is often studied using a model of experimental autoimmune myocarditis (EAM) in rats. Emodin is an important component of traditional Chinese herb rhubarb, and has well-documented anti-inflammatory effect. The current study determined the potential efficacy of emodin using a rat model of EAM. Male Lewis rats (6 weeks of age) were immunized on days 0 and 7 with a porcine cardiac myosin at both footpads to induce EAM. Simultaneously with the immunization, rats received emodin (50 mg/kg/day) or distilled water by intragastric administration for 3 weeks (8 animals/group). Likewise, eight animals were immunized with adjuvant alone and treated with distilled water. The immunization significantly enlarged the hearts due to inflammatory lesions. Emodin treatment significantly improved left ventricular (LV) function and reduced the severity of myocarditis, as reflected by echocardiographic and histopathological examination. Emodin treatment decreased the serum levels of proinflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-1β. Nuclear factor-κBp65 (NF-κBp65), a rapid-response transcription factor that regulates proinflammatory cytokines, in the myocardial tissue was also suppressed in the treated rats. In conclusion, emodin could ameliorate EAM, at least in part, by decreasing the production of proinflammatory cytokines TNF-α and IL-1β.

収録刊行物

  • Tohoku journal of experimental medicine

    Tohoku journal of experimental medicine 227(3), 225-230, 2012-07-01

    東北ジャーナル刊行会

参考文献:  43件中 1-43件 を表示

各種コード

  • NII論文ID(NAID)
    10030943971
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ