Emodin, a Naturally Occurring Anthraquinone, Ameliorates Experimental Autoimmune Myocarditis in Rats
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- Song Zhan-Chun
- Department of Cardiology, The First Hospital of China Medical University, China Medical University Department of Cardiology, Fushun Central Hospital
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- Wang Zhan-Sheng
- Department of Cardiology, The First Hospital of China Medical University, China Medical University
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- Bai Jing-Hui
- Department of Cardiology, The First Hospital of China Medical University, China Medical University Intensive care unit, Liaoning Cancer Hospital
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- Li Zhao
- Department of Cardiology, The First Hospital of China Medical University, China Medical University
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- Hu Jian
- Department of Cardiology, The First Hospital of China Medical University, China Medical University
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Abstract
Myocarditis is an inflammatory disease of the heart and a major cause of dilated cardiomyopathy that can lead to heart failure and sudden death in young adults. Giant cell myocarditis is a severe heart disease of unknown causes and is defined histopathologically as diffuse myocardial necrosis with multinucleated giant cells in the absence of sarcoid-like granulomata. Giant cell myocarditis is often studied using a model of experimental autoimmune myocarditis (EAM) in rats. Emodin is an important component of traditional Chinese herb rhubarb, and has well-documented anti-inflammatory effect. The current study determined the potential efficacy of emodin using a rat model of EAM. Male Lewis rats (6 weeks of age) were immunized on days 0 and 7 with a porcine cardiac myosin at both footpads to induce EAM. Simultaneously with the immunization, rats received emodin (50 mg/kg/day) or distilled water by intragastric administration for 3 weeks (8 animals/group). Likewise, eight animals were immunized with adjuvant alone and treated with distilled water. The immunization significantly enlarged the hearts due to inflammatory lesions. Emodin treatment significantly improved left ventricular (LV) function and reduced the severity of myocarditis, as reflected by echocardiographic and histopathological examination. Emodin treatment decreased the serum levels of proinflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-1β. Nuclear factor-κBp65 (NF-κBp65), a rapid-response transcription factor that regulates proinflammatory cytokines, in the myocardial tissue was also suppressed in the treated rats. In conclusion, emodin could ameliorate EAM, at least in part, by decreasing the production of proinflammatory cytokines TNF-α and IL-1β.
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 227 (3), 225-230, 2012
Tohoku University Medical Press
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Details 詳細情報について
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- CRID
- 1390001204243600128
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- NII Article ID
- 10030943971
- 130004460006
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- NII Book ID
- AA00863920
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- COI
- 1:CAS:528:DC%2BC38Xht12mtbvK
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- ISSN
- 13493329
- 00408727
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- PubMed
- 22791134
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed