Intrathoracic Rosai-Dorfman Disease with Spontaneous Remission : A Clinical Report and a Review of the Literature

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著者

    • NOGUCHI Shingo
    • Department of Respiratory Medicine, University of Occupational and Environmental Health
    • YATERA Kazuhiro
    • Department of Respiratory Medicine, University of Occupational and Environmental Health
    • SHIMAJIRI Shohei
    • Department of Pathology and Cell Biology, University of Occupational and Environmental Health
    • NAGATA Shuya
    • Department of Respiratory Medicine, University of Occupational and Environmental Health
    • NISHIDA Chinatsu
    • Department of Respiratory Medicine, University of Occupational and Environmental Health
    • KAWANAMI Toshinori
    • Department of Respiratory Medicine, University of Occupational and Environmental Health
    • ISHIMOTO Hiroshi
    • Department of Respiratory Medicine, University of Occupational and Environmental Health
    • SASAGURI Yasuyuki
    • Department of Pathology and Cell Biology, University of Occupational and Environmental Health
    • MUKAE Hiroshi
    • Department of Respiratory Medicine, University of Occupational and Environmental Health

抄録

Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare non-neoplastic disease that is characterized by a proliferation of histiocytes mostly in lymph nodes. However, the etiological mechanism of RDD still remains unclear. Intrathoracic manifestations of RDD are only observed in 2% of patients with RDD. Spontaneous remission was reported in about 20% of patients with RDD; however, there are no reports of an intrathoracic manifestation of RDD that showed a spontaneous remission within a short period of time. A 64-year-old Japanese female with dry cough and left chest pain was introduced to our hospital, and computed tomography revealed a pulmonary nodular lesion and enlarged mediastinal lymph nodes. The bronchial specimen obtained from the abnormal mucosal lesion showed massive infiltration of histiocytes underneath the bronchial epithelium and emperipolesis, a typical pathological finding in RDD, which is characterized by the presence of histiocyte-like cells engulfing intact lymphocytes. These histiocytes were positive for S-100 (one of the known positive markers of RDD) and for CD68 (a marker for various cells of the macrophage lineage). All these findings are consistent with the diagnosis of RDD. These radiological and endoscopic findings spontaneously resolved within four months without any treatment. In conclusion, clinicians should be aware of this disease as one of differential diagnoses of pulmonary nodules in combination with mediastinal lymph node enlargements, especially in order to differentiate it from primary lung cancer.

収録刊行物

  • Tohoku journal of experimental medicine

    Tohoku journal of experimental medicine 227(3), 231-235, 2012-07-01

    東北ジャーナル刊行会

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各種コード

  • NII論文ID(NAID)
    10030944015
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
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