The C-681G Polymorphism of the PPAR-γ Gene Is Associated with Susceptibility to Non-Alcoholic Fatty Liver Disease

この論文にアクセスする

この論文をさがす

著者

    • CAO Chuang-Yu
    • Department of Gastroenterology and Hepatology, Guangzhou Institute of Clinical Medicine, Guangzhou First Municipal People's Hospital, Guangzhou Medical College
    • LI Yu-Yuan
    • Department of Gastroenterology and Hepatology, Guangzhou Institute of Clinical Medicine, Guangzhou First Municipal People's Hospital, Guangzhou Medical College
    • ZHOU Yong-Jian
    • Department of Gastroenterology and Hepatology, Guangzhou Institute of Clinical Medicine, Guangzhou First Municipal People's Hospital, Guangzhou Medical College
    • NIE Yu-Qiang
    • Department of Gastroenterology and Hepatology, Guangzhou Institute of Clinical Medicine, Guangzhou First Municipal People's Hospital, Guangzhou Medical College
    • WAN Yu-Jui Yvonne
    • Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center

抄録

Non-alcoholic fatty liver disease (NAFLD) is defined as excessive accumulation of fatty acid in the liver, a common disease in the world. The research of single nucleotide polymorphisms (SNPs) provides a new approach for managing NAFLD. SNPs may increase or decrease the functions of the target genes and their encoding proteins. Peroxisome proliferator-activated receptor (PPAR) plays a key role in modulating metabolism of hepatic triglycerides and consequently magnitude of NAFLD. In this study, we investigated the effect of three SNPs in the PPAR-γ gene i.e. rs10865710 (C-681G), rs7649970 (C-689T) and rs1801282 (C34G, also termed Pro12Ala) on susceptibility to NAFLD. The participants were selected from our epidemiological survey. Totally 169 participants were enrolled in NAFLD group, and 699 healthy subjects were included as controls. PCR-RFLP was applied to detect the SNPs. The G allele frequency of rs10865710 in NAFLD group (41.1%) was significantly higher than that (34.8%) in controls (<i>p</i> = 0.03). Differences in other two loci (rs7649970 and rs1801282) were not statistically significant between the two groups (<i>p</i> > 0.05). This result was confirmed by haplotype analysis. The GCC haplotype (a set of 3 adjacent SNPs in linkage disequilibrium, corresponding to the three alleles of above polymorphisms in order) was a risk factor for the susceptibility to NAFLD (<i>p</i> = 0.03). This study has revealed that the G allele of rs10865710 in the PPAR-γ gene is associated with the increased susceptibility to NAFLD. Our findings may provide novel diagnostic biomarkers and therapeutic targets for NAFLD.

収録刊行物

  • Tohoku journal of experimental medicine

    Tohoku journal of experimental medicine 227(4), 253-262, 2012-08-01

    Tohoku University Medical Press

参考文献:  55件中 1-55件 を表示

各種コード

  • NII論文ID(NAID)
    10030944103
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ