A novel composite retrotransposon derived from or generated independently of the SVA (SINE/VNTR/Alu) transposon has undergone proliferation in gibbon genomes

この論文にアクセスする

この論文をさがす

著者

抄録

The superfamily Hominoidea (hominoids) comprises two families: Hominidae (hominids) and Hylobatidae (gibbons, also called small apes). The SVA transposon is a composite retrotransposon that occurs widely in hominoids and is considered to have been generated by stepwise fusions of three genetic elements: SINE-R, a variable number of tandem repeat (VNTR) sequence, and <i>Alu</i>. We identified a novel transposon whose basic structure is the same as that of SVA, with one prominent difference being the presence of part of <i>prostaglandin reductase 2</i> (<i>PTGR2</i>) in place of SINE-R. We designate this composite transposon as PVA and propose two possible mechanisms regarding its generation. One is the derivation of PVA from SVA: the SINE-R region of SVA was replaced with a <i>PTGR2</i> fragment by template switching. The other is the formation of PVA independently of SVA: a <i>PTGR2</i> fragment was fused to an evolutionary intermediate comprising the VNTR and <i>Alu</i> regions. The nucleotide sequence of the junction between the VNTR and <i>PTGR2</i> regions supports the second hypothesis. We identified PVA in the white-cheeked gibbon <i>Nomascus leucogenys</i> by analysis of genome sequence databases, and subsequent experimental analysis revealed its presence in all four gibbon genera. The white-cheeked gibbon harbors at least 93 PVA copies in its haploid genome. Another SVA-like composite transposon carrying parts of the LINE1 and <i>Alu</i> transposons in place of SINE-R, designated as LAVA, has recently been reported. The significance of the discovery of PVA is that its substituted fragment originates not from a transposon but from a single-copy gene. PVA should provide additional insights into the transposition mechanism of this type of composite transposon; the transposition activity is conferred even if the substituted fragment is not related to a transposon.

収録刊行物

  • Genes & genetic systems

    Genes & genetic systems 87(3), 181-190, 2012-06-25

    日本遺伝学会

参考文献:  27件中 1-27件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10030945244
  • NII書誌ID(NCID)
    AA11077421
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13417568
  • NDL 記事登録ID
    023856522
  • NDL 請求記号
    Z53-W539
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ