PCRが陰性で, 培養により新型インフルエンザウイルスが同定された重症肺炎の1症例 A Case of Severe Influenza (H1N1) 2009 Virus Pneumonia Identified by Virus Culture Instead of PCR

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著者

    • 駒瀬 裕子 KOMASE Yuko
    • 聖マリアンナ医科大学横浜市西部病院呼吸器内科 Department of Respiratory Internal Medicine, St. Marianna University, School of Medicine, Yokohama-City Seibu Hospital
    • 石田 明 ISHIDA Akira
    • 聖マリアンナ医科大学横浜市西部病院呼吸器内科 Department of Respiratory Internal Medicine, St. Marianna University, School of Medicine, Yokohama-City Seibu Hospital
    • 森田 あかね [他] MORITA Akane
    • 聖マリアンナ医科大学横浜市西部病院呼吸器内科 Department of Respiratory Internal Medicine, St. Marianna University, School of Medicine, Yokohama-City Seibu Hospital
    • 山口 裕礼 YAMAGUCHI Hiromichi
    • 聖マリアンナ医科大学横浜市西部病院呼吸器内科 Department of Respiratory Internal Medicine, St. Marianna University, School of Medicine, Yokohama-City Seibu Hospital

抄録

A 70-year-old man was being treated for asthma and chronic obstructive pulmonary disease, which had been well controlled. He was seen at our emergency outpatient department on October 24, 2009, for respiratory distress and mild fever. Point-of-care testing for influenza, general bacteria, and acid-fast bacilli in the sputum, were negative. With antibiotics ineffective, his respiratory status worsened, requiring him to be intubated and ventilated mechanically. Steroid pulse therapy temporarily improved his condition, as confirmed by imaging studies, but he died on hospital day 38. Polymerase chain reaction (PCR) analysis of tracheal secretion and bronchial washings collected on hospital day 14 and 21 were negative for influenza (H1N1) 2009 virus, which was identified in a subsequent culture. Negative results for reverse transcriptase-PCR analysis leave (H1N1) 2009 virus unable to be diagnosed clinically. Culture tests and repeated PCR analysis have been done in cases of strongly suspected clinical infection to confirm results. Our case, in which the virus was identified by culture, suggests that the viral load may have been too low or the time of culture inappropriate.

収録刊行物

  • 感染症学雑誌 : 日本伝染病学会機関誌 : the journal of the Japanese Association for Infectious Diseases

    感染症学雑誌 : 日本伝染病学会機関誌 : the journal of the Japanese Association for Infectious Diseases 85(6), 670-673, 2011-11-20

    一般社団法人 日本感染症学会

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各種コード

  • NII論文ID(NAID)
    10030950341
  • NII書誌ID(NCID)
    AN00047715
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    03875911
  • NDL 記事登録ID
    023443286
  • NDL 請求記号
    Z19-193
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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