Effects of Cyclooxygenase-2 Inhibitor on Equine Gastric Mucosa

DOI IR JASI Web Site Web Site 28 References
  • YAMAGA Takashi
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
  • TSUZUKI Nao
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
  • SEO Jong-pil
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
  • OSHITA Noe
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
  • NAKAO Syogo
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
  • TANABE Takafumi
  • SASAKI Naoki
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine

Bibliographic Information

Other Title
  • 馬におけるフェニルブタゾンとシクロオキシゲナーゼ-2選択阻害薬投与による胃粘膜への影響
  • ウマ ニ オケル フェニルブタゾン ト シクロオキシゲナーゼ-2 センタク ソガイヤク トウヨ ニ ヨル イ ネンマク エ ノ エイキョウ

Search this article

Abstract

This study was performed to evaluate the effects of Cyclooxygenase-2 inhibitor on equine gastric mucosa. Six healthy thoroughbred horses each received saline (20 ml), phenylbutazone (4.4 mg/kg), firocoxib (5.0 mg/kg), and a combination of omeprazole and phenylbutazone (1.0 and 4.4 mg/kg, respectively) perorally once a day for 7 days with a 14-day washout period between treatments. Gastric mucosa was evaluated using gastric endoscopy before and seven days after treatment. In phenylbutazone treatment, an ulcer of 2.0 cm in diameter was observed in margo plicatus, and the ulcer score increased significantly at day 7. With the other treatments, the ulcer score did not change. These results indicate that the omeprazole has a preventive effect on gastric ulcer induced by phenylbutazone, and firocoxib has less effect on equine gastric mucosa than phenylbutazone does.

Journal

References(28)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top