Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker

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  • Kushida Masahiko
    Department of Pathology, Osaka City University Medical School Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
  • Wanibuchi Hideki
    Department of Pathology, Osaka City University Medical School
  • Wei Min
    Department of Pathology, Osaka City University Medical School
  • Kakehashi Anna
    Department of Pathology, Osaka City University Medical School
  • Ozaki Keisuke
    Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
  • Sukata Tokuo
    Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
  • Miyata Kaori
    Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
  • Ogata Keiko
    Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
  • Uwagawa Satoshi
    Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
  • Fukushima Shoji
    Department of Pathology, Osaka City University Medical School Japan Bioassay Research Center, Japan Industrial Safety and Health Association

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Abstract

Epidemiological studies suggest that alcohol consumption increases the risk of developing colorectal cancer. However, the data are confounded by numerous cosegregating variables. To cast further light on the relationships between alcohol intake and colon cancer development, 21-day-old male F344/DuCrj rats were fed 200 ppm 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in their diet for 8 weeks and doses of 0, 0.1, 0.3, 1, 3, 10 and 20% of ethanol in their drinking water ad libitum for 16 weeks thereafter. The rats were sacrificed after 24 weeks of experiment, and aberrant crypt foci (ACF), surrogate lesions for colon cancer, were examined under a light microscope at low magnification. Ethanol was found not to affect the ACF formation at any dose compared with the initiated-controls. Furthermore, ethanol did not alter colon epithelial cell proliferation. These data, obtained by analysis of a colon cancer surrogate marker lesion, indicate that ethanol lacks promotion activity for MeIQx-initiated rat colon carcinogenesis. <br>

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