Metabolic Fingerprinting in Toxicological Assessment Using FT-ICR MS

DOI Web Site Web Site 56 References
  • Hasegawa Mina
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • Ide Mika
    Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
  • Kuwamura Mitsuru
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • Yamate Jyoji
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
  • Takenaka Shigeo
    Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University

Search this article

Abstract

Detection of the toxicity of a candidate compound at an early stage of drug development is an emerging area of interest. It is difficult to determine all of the effects of metabolism of a compound using traditional approaches such as histopathology and serum biochemistry. The goal of a metabolomics approach is to determine all metabolites in a living system, with the potential to detect and identify biomarkers involved in toxicity onset. Here, we summarize the metabolic fingerprints for detection and identification of metabolic changes and biomarkers related to drug-induced toxicity using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). <br>

Journal

References(56)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top