Phospholipid Scrambling on Plasma Membrane

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  • Suzuki Jun
    Department of Medical Chemistry, Kyoto University Graduate School of Medicine
  • Nagata Shigekazu
    Department of Medical Chemistry, Kyoto University Graduate School of Medicine

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Other Title
  • 細胞膜リン脂質のスクランブル機構
  • 講演録 細胞膜リン脂質のスクランブル機構
  • コウエンロク サイボウマク リン シシツ ノ スクランブル キコウ

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Abstract

Phospholipids on plasma membranes are asymmetrically distributed between inner and outer leaflets. ATPdependent flippases or aminophospholipid translocases regulate the asymmetry of phospholipids, especially the inner location of phosphatidylserine (PS), while calcium-dependent scramblases disrupt this asymmetry, and as a result of that, PS is exposed on the cell surface. PS exposure is biologically important in clearance of apoptotic cells and platelet clotting. However, it is unknown how PS is exposed on the cell surface. In this talk, I will discuss how PS is exposed on the cell surface.

Journal

  • MEMBRANE

    MEMBRANE 37 (4), 174-178, 2012

    THE MEMBRANE SOCIETY OF JAPAN

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