Clinical Significance of DNA aneuploidy in gastro-intestinal cancers

• Ando Koji

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

• Zhao Yan

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

• Oki Eiji

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

• Kitao Hirouki

  Department of Molecular Oncology, Graduate School of Medical Sciences, Kyushu University

• Saeki Hiroshi

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

• Kakeji Yoshihiro

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

• Kimura Yasue

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

• Ida Satoshi

  Department of Gastroenteroogical Surgery, Graduate School of Medical Sciences, Kumamoto University

• Morita Masaru

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

• Kusumoto Tetsuya

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

• Maehara Yoshihiko

  Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title

• 消化器癌におけるDNA aneuploidy の意義

Abstract

Genomic instability, frequently observed in cancers, has two types: chromosomal instability, CIN and microsatellite instability, MIN. It is reported that aberration of spindle assembly check-point (SAC) and mutation of TP53 gene is frequently observed in CIN, while precise mechanism of how CIN occur is not known. To discover the significance of DNA aneuploidy and its mechanism, we analyzed DNA ploidy status in gastric cancer and colorectal cancer clinical samples. We also analyzed MSI status, a marker for MIN, in the same samples and found that DNA aneuploidy and MSI (+) have reverse correlation. The expression of BUBR1, one of the important factors in SAC, was analyzed in gastric cancer sample. High expression of BUBR1 had significant relationship with DNA aneuploidy. To introduce the significance of DNA aneuploidy in gastro-intestinal cancers, we will discuss about DNA ploidy status, MSI status and the expression of BUBR1 in this study.

Journal

• Cytometry Research

  Cytometry Research 22 (2), 15-20, 2012

  Japan Cytometry Society

Keywords

• DNA aneuploidy
• MSI
• gastric cancer
• colorectal cancer

Details

• CRID: 1390001204472461824
• NII Article ID: 10031026118
• NII Book ID: AN10356261
• DOI: 10.18947/cytometryresearch.22.2_15
• ISSN: 24240664
• ISSN: 09166920
• Web Site: https://search.jamas.or.jp/link/ui/2013081951
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed