Associations of <i>apolipoprotein A5 (APOA5), glucokinase (GCK)</i> and <i>glucokinase regulatory protein (GCKR)</i> polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese — a cross-sectional data from the J-MICC Study

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  • Hishida Asahi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Morita Emi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Naito Mariko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Okada Rieko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Wakai Kenji
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
  • Matsuo Keitaro
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
  • Nakamura Kazuyo
    Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan
  • Takashima Naoyuki
    Department of Health Science, Shiga University of Medical Science, Otsu 520-2192, Japan Department of Health Science, Shiga University of Medical Science, Otsu 520-2192, Japan
  • Suzuki Sadao
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
  • Takezaki Toshiro
    Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
  • Mikami Haruo
    Division of Epidemiology, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan Division of Epidemiology, Chiba Cancer Center Research Institute, Chiba 260-8717, Japan
  • Ohnaka Keizo
    Department of Geriatric Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan Department of Geriatric Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan
  • Watanabe Yoshiyuki
    Department of Social Medicine and Cultural Sciences, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan Department of Social Medicine and Cultural Sciences, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  • Uemura Hirokazu
    Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan
  • Kubo Michiaki
    Center for Genomic Medicine, RIKEN, Yokohama 230-0045, Japan. Center for Genomic Medicine, RIKEN, Yokohama 230-0045, Japan
  • Tanaka Hideo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
  • Hamajima Nobuyuki
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan

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Other Title
  • Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese—a cross-sectional data from the J-MICC Study

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Abstract

This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with serum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dyslipidemia was defined as fasting serum triglycerides (FTG) ≥ 150 mg/dL and/or HDL-cholesterol (HDL-C) < 40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) ≥ 110 mg/dL. When those with APOA5 -1131 T/T or 553 G/G were defined as references, those with APOA5 -1131 T/C, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95% confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively). Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FTG and HDL-C levels were significantly associated with the APOA5 T-1131C and G553T polymorphisms, FTG with the GCKR rs780094 and rs1260326 polymorphisms, and FBS with the GCKR rs780094 and rs1260326 polymorphisms. Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake ≥ 25% of total energy for the risk of dyslipidemia was observed. Our cross-sectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.

Journal

  • Endocrine Journal

    Endocrine Journal 59 (7), 589-599, 2012

    The Japan Endocrine Society

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