Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight

• Bai Yunzhe

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Tsunematsu Takashi

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Jiao Qibin

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Ohnuki Yoshiki

  Department of Physiology, Tsurumi University School of Dental Medicine, Japan

• Mototani Yasumasa

  Department of Physiology, Tsurumi University School of Dental Medicine, Japan

• Shiozawa Kouichi

  Department of Physiology, Tsurumi University School of Dental Medicine, Japan

• Jin Meihua

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Cai Wenqian

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Jin Hui-Ling

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Fujita Takayuki

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Ichikawa Yasuhiro

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Suita Kenji

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Kurotani Reiko

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan Biochemical Engineering, Faculty of Engineering, Yamagata University, Japan

• Yokoyama Utako

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Sato Motohiko

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan

• Iwatsubo Kousaku

  Cardiovascular Research Institute, Department of Cell Biology & Molecular Medicine and Medicine (Cardiology), New Jersey Medical School of UMDNJ, USA

• Ishikawa Yoshihiro

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan Cardiovascular Research Institute, Department of Cell Biology & Molecular Medicine and Medicine (Cardiology), New Jersey Medical School of UMDNJ, USA

• Okumura Satoshi

  Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Japan Department of Physiology, Tsurumi University School of Dental Medicine, Japan

抄録

We previously demonstrated that type 5 adenylyl cyclase (AC5) functions in autonomic regulation in the heart. Based on that work, we hypothesized that pharmacological modulation of AC5 activity could regulate the autonomic control of the heart rate under micro- and hypergravity. To test this hypothesis, we selected the approach of activating AC5 activity in mice with a selective AC5 activator (NKH477) or inhibitor (vidarabine) and examining heart rate variability during parabolic flight. The standard deviation of normal R-R intervals, a marker of total autonomic variability, was significantly greater under micro- and hypergravity in the vidarabine group, while there were no significant changes in the NKH477 group, suggesting that autonomic regulation was unstable in the vidarabine group. The ratio of low frequency and high frequency (HF) in heart rate variability analysis, a marker of sympathetic activity, became significantly decreased under micro- and hypergravity in the NKH477 group, while there was no such decrease in the vidarabine group. Normalized HF, a marker of parasympathetic activity, became significantly greater under micro- and hypergravity in the NKH477 group. In contrast, there was no such increase in the vidarabine group. This study is the first to indicate that pharmacological modulation of AC5 activity under micro- and hypergravity could be useful to regulate the autonomic control of the heart rate.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 119 (4), 381-389, 2012

  公益社団法人 日本薬理学会

キーワード

• adenylyl cyclase isoform
• autonomic nerve activity
• parabolic flight
• heart rate variability
• microgravity

詳細情報

• CRID: 1390001205180164352
• NII論文ID: 10031071685
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.12102fp
• COI: 1:CAS:528:DC%2BC38XhtlagtbnM
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 023892469
• PubMed: 22850613
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023892469
• Web Site: https://search.jamas.or.jp/link/ui/2013156959
• 本文言語コード: en
• データソース種別:
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  • NDL
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