ユビキノールによるビタミンEの再生反応に及ぼす金属塩の効果とメカニズム

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タイトル別名
  • Kinetic Study of the α-Tocopherol-Regeneration Reaction of Ubiquinol-10 : Notable Effect of the Alkali and Alkaline Earth Metal Salts on the Reaction Rates
  • ユビキノール ニ ヨル ビタミン E ノ サイセイ ハンノウ ニ オヨボス キンゾクエン ノ コウカ ト メカニズム

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抄録

A kinetic study of regeneration reaction of α-tocopherol (α-TocH) by ubiquinol-10 has been performed in the presence of alkali and alkaline earth metal salts in methanol and acetonitrile solutions. Notable effects of metal cations on the UV-Vis absorption spectrum of α-tocopheroxyl (α-Toc・) radical were observed in aprotic acetonitrile solution, suggesting a complex formation between α-Toc・ and metal cations. On the other hand, effects of metal cations were negligible in protic methanol, suggesting that the complex formation between α-Toc・ and metal cations is hindered by the hydrogen bond between α-Toc・ and methanol molecules. The second-order rate constants (k_r) for the reaction of α-Toc・ with ubiquinol-10 increased and decreased notably with increasing concentrations of metal salts in methanol and acetonitrile, respectively. The difference in the reaction mechanism in methanol and acetonitrile was discussed based on the results obtained. High concentrations of alkali and alkaline earth metal salts coexist with α-TocH and ubiquinol-10 in plasma, blood and many tissues, suggesting the contribution of the metal salts to the above regeneration reaction in biological systems.

収録刊行物

  • ビタミン

    ビタミン 86 (5-6), 293-302, 2012

    公益社団法人 日本ビタミン学会

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