Development and Performance Evaluation of the Oxygenator for Total Liquid Ventilation

DOI 18 References
  • Yokoi Ryo
    Graduate School of Advanced Science and Technology, Graduate School of Tokyo Denki University
  • Hata Norihiko
    Frontier Research and Development Center, Tokyo Denki University,
  • Nonaka Kazuhiro
    School of Science and Engineering, Tokyo Denki University
  • Fukui Yasuhiro
    Graduate School of Advanced Science and Technology, Graduate School of Tokyo Denki University
  • Funakubo Akio
    Graduate School of Advanced Science and Technology, Graduate School of Tokyo Denki University

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  • 完全液体呼吸専用人工肺の開発および性能評価

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Abstract

Total Liquid Ventilation (TLV) is an effective treatment for severe respiratory failure, however, TLV still remains the problem of CO2 removal. In this study, the membrane oxygenator for TLV (TLV-OX) was developed to introduce into the recirculation TLV system. The in-vitro experiment with the recirculation TLV system were conducted as TLV-OX performance evaluations. The experiment was performed for 1 hrs with 40 mL tidal volume, respiratory rate of 8 breath.min-1, I:E ratio of 1:1 and Perfluorocarbon(PFC) flow rate of 1.5 L.min-1. As the result, PpO2 and PpCO2 were kept in the normal value (PpO2 > 400 mmHg, PpCO2 < 5 mmHg). On receiving the results we conducted ex-vivo evaluation experiments by the use of living lung. The experiment was performed for 3 hrs with 17 mL.kg-1 tidal volume, I:E ratio of 1:1 and PFC flow rate of 1.5 L.min-1. As the result, 3 of 4 rabbits were able to achieve TLV for 3 hrs. And it was possible to maintain PaO2 100-500 mmHg, PaCO2 35-45 mmHg in newly developed TLV system.

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