<b>Maternal-to-Fetal Transfer of Ritodrine in Twin Pregnancy </b>

DOI 2 Citations 31 References
  • SOMA Mayuko
    Department of Pharmacy, Tenshi Hospital
  • KONDA Ainari
    Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy
  • YOSHIDA Hiroshi
    Department of Obstetrics and Gynecology, Tenshi Hospital
  • KISHIMOTO Shuichi
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
  • FUKUSHIMA Shoji
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
  • TODA Takaki
    Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy
  • SASAKI Yoichi
    Department of Pharmacy, Tenshi Hospital
  • HAYAKAWA Toru
    Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy
  • INOTSUME Nobuo
    Division of Clinical Pharmacology, Hokkaido Pharmaceutical University School of Pharmacy

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  • Maternal-to-Fetal Transfer of Ritodrine in Twin Pregnancy

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Abstract

Aims: Little is known about the maternal-to-fetal transfer ratio of ritodrine in women who are pregnant with twins and undergoing treatment with ritodrine for threatened premature delivery. We aimed to investigate the maternal-to-fetal transfer ratio for establishing rational ritodrine therapy.<br>Methods: Ritodrine concentrations were measured by HPLC in maternal and umbilical venous blood samples during continuous intravenous ritodrine infusion in 14 women who were expecting dizygotic twins.<br>Results: The maternal concentration range of ritodrine required to maintain pregnancy was 21.8-126.0 ng/mL. Serum concentrations of ritodrine did not differ significantly between the first and second twin neonates, but the maternal-to-fetal transfer ratio was significantly lower for the first than for the second twin neonate (means±SD, range: 1.05±0.23, 0.65-1.40 vs. 1.15±0.26, 0.75-1.64).<br>Conclusion: The concentrations of maternal ritodrine transferred to the umbilical veins of newborn twins were essentially equal, but the transfer ratios varied significantly between the first twin and the second twin. Further studies are required to establish rational ritodrine therapy. (Jpn J Clin Pharmacol Ther 2012; 43(5): 339-343)

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