Extension of Chronological Lifespan by <i>Sc</i>Ecl1 Depends on Mitochondria in <i>Saccharomyces cerevisiae</i>

• AZUMA Kenko

  Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University

• OHTSUKA Hokuto

  Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University

• MURAKAMI Hiroshi

  Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University

• AIBA Hirofumi

  Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University

Bibliographic Information

Other Title

• Extension of Chronological Lifespan by ScEcl1 Depends on Mitochondria in Saccharomyces cerevisiae

Abstract

Ecl1, a product of the YGR146C gene in Saccharomyces cerevisiae, was identified as a factor involved in chronological lifespan. In this study we found evidence that the function of Ecl1 in the extension of chronological lifespan is dependent on mitochondrial function. The respiratory activity of cells increased when Ecl1 was overexpressed or cells were grown under calorie restriction, but there was no additive effect of calorie restriction and Ecl1 overexpression on increases in respiratory activity or on the extension of chronological lifespan. Based on these results, we propose that overexpression of Ecl1 has same effect as caloric restriction and that its function also depends on mitochondria, just like caloric restriction.

Journal

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 76 (10), 1938-1942, 2012

  Japan Society for Bioscience, Biotechnology, and Agrochemistry

Keywords

• chronological lifespan
• yeast
• Ecl1
• mitochondria
• respiration

Details

• CRID: 1390282681455075840
• NII Article ID: 130004054018
• NII Article ID: 10031126484
• NII Book ID: AA10824164
• DOI: 10.1271/bbb.120427
• COI: 1:STN:280:DC%2BC3s%2FjsFGltw%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL BIB ID: 024035956
• PubMed: 23047113
• Web Site: http://id.ndl.go.jp/bib/024035956
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024035956
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.120427
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed