Histopathological Changes in Surrounding Tissue of the Sciatic Nerve after Spinal Cord Injury in Rats

• Kitade Ippei

  Division of Rehabilitation Medicine, University of Fukui Hospital

• Hoso Masahiro

  Division of Health Sciences, Kanazawa University Graduate School of Medical Science

• Matsuzaki Taro

  Division of Health Sciences, Kanazawa University Graduate School of Medical Science

• Yoshida Shinya

  Department of Rehabilitation Medicine, Kanazawa University Hospital

• Kamijyo Akio

  Department of Rehabilitation Medicine, Azumino Red Cross Hospital

• Araki Yoshitaka

  Department of Rehabilitation Medicine, Kanazawa Cranial Nerve Surgery Hospital

• Takahashi Ikufumi

  Department of Rehabilitation Medicine, Houju Memorial Hospital

Abstract

[Purpose] The purpose of this study was to examine histopathological changes in tissue surrounding the sciatic nerve after spinal cord injury (SCI) in rats. [Subjects and Methods] Thirty adult, nine-week-old, female Wistar rats were used in this study. Fifteen experimental rats underwent spinal cord transection at the level of Th8-9 and the other fifteen control rats were raised normally. Animals were assessed at 1, 2, 4, 8, and 12 weeks following surgery. After the experimental period, we obtained tissue surrounding the sciatic nerve of the thigh after hematoxylin and eosin staining under a microscope. [Results] Adherence between the nerve bundle and perineural innermost layer was observed in tissue surrounding the sciatic nerve in the SCI group. Adherence among the inter-perineurium was evident at 2 weeks after SCI. It had declined at 4 weeks after SCI, but was still evident at 8 and 12 weeks after SCI. [Conclusion] Histopathological findings in the SCI model may be related to compression of the nerve bundle and neurogenic contracture of tissue surrounding the nerve bundle.

Journal

• Journal of Physical Therapy Science

  Journal of Physical Therapy Science 24 (9), 817-820, 2012

  The Society of Physical Therapy Science

Keywords

• Spinal cord injury
• Sciatic nerve
• Perineurium

Details

• CRID: 1390001204327731968
• NII Article ID: 10031127072
• NII Article ID: 130004431878
• NII Book ID: AA10798949
• DOI: 10.1589/jpts.24.817
• ISSN: 21875626
• ISSN: 09155287
• HANDLE: 2297/34708
• Web Site: https://kanazawa-u.repo.nii.ac.jp/records/13918
• Web Site: https://www.jstage.jst.go.jp/article/jpts/24/9/24_817/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013276221
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed