Status of Soft-Contact Lens Biosensor Development towards Tear Sugar Monitoring: A Review

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  • Kudo Hiroyuki
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • Arakawa Takahiro
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • Mitsubayashi Kohji
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

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  • 涙液糖モニタリング用ソフトコンタクトレンズ型バイオセンサの開発状況と将来展望（レビュー）
  • ルイエキ トウ モニタリングヨウ ソフトコンタクトレンズガタ バイオセンサ ノ カイハツ ジョウキョウ ト ショウライ テンボウ(レビュー)

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Abstract

Non-invasive and continuous glucose monitoring is of increasing significance since diabetes mellitus has been a global problem, not only the developed country. Usually, continuous glucose monitors (CGMs) use relationship between blood glucose and other body fluids. Particularly, we focused on the relationship between blood glucose and tear glucose. A soft-contact lens (SCL) biosensor has been developed for assessment of blood glucose by real-time tear sugar monitoring. The SCL biosensor has film electrodes on the rounded surface of polydimethyl siloxane (PDMS) contact-lens and glucose oxidase (GOD) was immobilized on the sensing region of the electrodes. In this paper, the status of SCL biosensor development and the application of the SCL biosensor in real-time monitoring of tear glucose are reviewed.

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