Designing Caged Compounds for Spatiotemporal Control of Cellular Chemistry

• Furuta Toshiaki

  Department of Biomolecular Science, Faculty of Science, Toho University

Abstract

Photoirradiation of an appropriately designed caged compound enables the control and manipulation of biological processes in living cells with high spatial and temporal resolution. Brominated (coumarin-4-yl)methyl groups were designed to have favorable photochemical and physical properties as photoremovable protecting groups of caged compounds. Caged compounds of various types of biologically related molecules including neurotransmitters, second messengers, inhibitors of some proteins and mRNAs have been synthesized. A membrane-permeable caged cGMP, Bhc-cGMP/Ac, controlled a cGMP-dependent signaling pathway in a freely swimming sperm cell. Spot illumination of Bhcmoc-diC8 produced localized accumulation of diacylglycerol in a single T-cell.

Journal

• Journal of Synthetic Organic Chemistry, Japan

  Journal of Synthetic Organic Chemistry, Japan 70 (11), 1164-1169, 2012

  The Society of Synthetic Organic Chemistry, Japan

Keywords

• Organic Chemistry

Details

• CRID: 1390282680316016896
• NII Article ID: 10031131195
• NII Book ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.70.1164
• COI: 1:CAS:528:DC%2BC38XhslCjsrvE
• ISSN: 18836526
• ISSN: 00379980
• NDL BIB ID: 024087911
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024087911
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed