Effect of Low-voltage Pulse on Cell Elimination

Hidenori Otsuka, Saya Okimura, Masako Nagamura, Daisuke Matsukuma, Koichi Kutsuzawa, Naoki Matsuda, Tatsuro Nakashima, Hirotaka Okabe

doi:10.1246/cl.2012.1636

Effect of Low-voltage Pulse on Cell Elimination

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Hidenori Otsuka

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
Saya Okimura

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
Masako Nagamura

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
Daisuke Matsukuma

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
Koichi Kutsuzawa

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science
Naoki Matsuda

Measurement Solution Research Center, National Institute of Advanced Industrial Science and Technology (AIST) Kyusyu
Tatsuro Nakashima

Measurement Solution Research Center, National Institute of Advanced Industrial Science and Technology (AIST) Kyusyu
Hirotaka Okabe

Measurement Solution Research Center, National Institute of Advanced Industrial Science and Technology (AIST) Kyusyu

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<jats:title>Abstract</jats:title> <jats:p>The low electric field application to HeLa cells adhered to electrodes was studied to induce cell death effectively. The low-voltage pulse applied to the electrode was generated with charge and discharge by an originally made circuit. The unique characteristics in this experiment is the charge flow between electrodes, and it causes direct attack of the ions to the cell membrane, leading to complete cell elimination. Viability of cells appreciably decreased with increase in discharge time at a quite low 3 V cm−1 that has not been reported to date.</jats:p>