Exposure to diesel exhaust during fetal period affects behavior and neurotransmitters in male offspring mice

DOI Web Site Web Site PubMed 被引用文献7件 参考文献67件
  • Yokota Satoshi
    The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Moriya Nozomu
    Department of Biopharmaceutics, Hyogo University of Health Sciences
  • Iwata Mari
    Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Umezawa Masakazu
    The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science
  • Oshio Shigeru
    Department of Hygiene Chemistry, School of Pharmaceutical Sciences, Ohu University
  • Takeda Ken
    The Center for Environmental Health Science for the Next Generation, Research Institute for Science and Technology, Tokyo University of Science Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

この論文をさがす

抄録

Exposure to ambient particulate matter (PM) has been associated with the onset of cardiovascular and respiratory diseases. Diesel exhaust particles (DEP) are major components of ambient PM. We first reported DEP in the central nervous system of offspring utilizing maternal inhalation to diesel exhaust (DE). In addition, we found that the effects of maternal exposure to DE reduced spontaneous motor activity. However, it is still unknown whether maternal exposure to DE affects higher order behavioral function. Therefore, the aim of the present study was to examine the effects of fetal exposure to DE on motor coordination, impulsive behavior and monoaminergic systems in various brain regions. The results of the rotating rod test showed that DE-exposed mice displayed decreased time on the rota rod compared to control mice. However, no changes were detected between the two groups in the hanging test. Furthermore, the cliff avoidance test revealed that DE-exposed mice spent more time in the corner and fell off an inverted glass beaker compared to control mice. High performance liquid chromatography analysis revealed that noradrenaline turnover in the cerebellum was decreased by prenatal exposure to DE, and was significantly increased in the hypothalamus. Dopamine and serotonin levels in various brain regions were also changed by prenatal exposure to DE. Our study found that prenatal exposure to DE alters motor coordination, impulsive behavior and related monoamine levels. Therefore, the present study underscores the role of behavioral changes related to monoamine in response to maternal inhalation of DE.

収録刊行物

被引用文献 (7)*注記

もっと見る

参考文献 (67)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ