Microarray analysis of neonatal brain exposed to cadmium during gestation and lactation

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  • Honda Akiko
    Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University
  • Watanabe Chiho
    Department of Human Ecology, School of International Health, Graduate School of Medicine, University of Tokyo
  • Yoshida Minoru
    Faculty of Human Health Science, Hachinohe University
  • Nagase Hisamitsu
    Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University
  • Satoh Masahiko
    Department of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University

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  • Toxicomics Report : Microarray analysis of neonatal brain exposed to cadmium during gestation and lactation

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Abstract

DNA microarray containing 30,000 genes was used to monitor the transcriptional response of the neonatal brain after cadmium (Cd) exposure. C57BL/6J pregnant mice were exposed to Cd (10 ppm) during gestation and lactation via drinking water. In a comparison between the Cd-exposed neonatal brain and control, three genes including transferrin receptor (Tfrc) were up-regulated and one gene was down-regulated.

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