Diagnosis and Assessment of Takayasu Arteritis by Multiple Biomarkers
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- Ishihara Takashi
- Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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- Haraguchi Go
- Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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- Tezuka Daisuke
- Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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- Kamiishi Tetsuo
- Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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- Inagaki Hiroshi
- Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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- Isobe Mitsuaki
- Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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Background: Patients with Takayasu arteritis (TA) often show recurrence under steroid treatment without an elevation of C-reactive protein (CRP). There is a report that matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and pentraxin3 (PTX3) could be sensitive biomarkers, but the characteristics of these biomarkers have not been established. Methods and Results: We enrolled 45 consecutive patients; 28 were grouped in an active phase as evidenced by clinical recurrence within 2 years of blood sampling. Circulating levels of high-sensitivity (hs)CRP, MMPs, and PTX3 were determined. Patients in an active phase showed higher levels of hsCRP, MMP-9, and PTX3. Area under the receiving operating characteristics curves of hsCRP and PTX3 were significantly higher than that of MMP-9. Among the 28 patients with active TA, 71% was positive for hsCRP and 82% for PTX3. Patients without recurrence showed significantly higher plasma levels of MMP-9. There was a positive correlation between the plasma MMP-3 level and the prednisolone dose. However, PTX3 and MMP-9 levels did not have such a correlation. Conclusions: PTX3 and MMP-9, which are not affected by prednisolone, could be sensitive biomarkers for assessing TA activity. Evaluation of MMP-9 may suggest prior existence of TA. (Circ J 2013; 77: 477–483)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 77 (2), 477-483, 2013
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680082160512
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- NII論文ID
- 10031138928
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- NII書誌ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BC3sXislyitbo%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 23100088
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可