Simultaneous Heart Rate Variability Monitoring Enhances the Predictive Value of Flow-Mediated Dilation in Ischemic Heart Disease

• Watanabe Shogo

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo Department of Laboratory Medicine, Teikyo University School of Medical Technology

• Amiya Eisuke

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Watanabe Masafumi

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Takata Munenori

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Ozeki Atsuko

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Watanabe Aya

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Kawarasaki Shuichi

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Nakao Tomoko

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Hosoya Yumiko

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Omori Kazuko

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo Department of Laboratory Medicine, Teikyo University School of Medical Technology

• Maemura Koji

  Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Komuro Issei

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Nagai Ryozo

  Jichi Medical University Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

抄録

Background: Endothelial dysfunction and autonomic nervous system imbalance are both risk markers of atherosclerotic vascular damage. The relationship between these 2 factors, however, has not been clarified concisely. Methods and Results: Flow-mediated dilation (FMD) was measured in 47 patients with ischemic heart disease (IHD; mean age, 68.1±7.1 years) using an ultrasound semi-automatic measuring system (UNEXEF18G), and autonomic nervous system activity was evaluated by simultaneous measurements of heart rate variability. FMD was significantly correlated with standard deviation of normal-to-normal beats (r=0.33, P=0.022) and the power ratio of low-frequency power to high-frequency power (LF/HF; r=–0.38, P=0.0087). Furthermore, multiple regression analysis indicated that LF/HF was the most important predictor of the magnitude of FMD. This interaction was severely blunted by β-blockers and the presence of diabetes. Moreover, standardized FMD according to autonomic nervous system activity was a better predictor of future cardiovascular events than FMD. Subjects with cardiovascular events had a significantly smaller corrected FMD (event (+), 3.62±0.41; event (–), 5.10±2.35; P=0.001), and the higher corrected FMD was associated with longer event-free survival. Conclusions: Autonomic nervous system activity is an important regulatory factor of FMD in subjects with IHD. Assessment of this interaction can help provide more accurate risk stratification of subjects with IHD.  (Circ J 2013; 77: 1018–1025)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 77 (4), 1018-1025, 2013

  一般社団法人 日本循環器学会

キーワード

• Autonomic nervous system
• Endothelial function
• Flow-mediated dilation
• Ischemic heart disease

詳細情報

• CRID: 1390001205103417472
• NII論文ID: 10031139006
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-12-1043
• COI: 1:STN:280:DC%2BC3s3hvVajsQ%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 23238368
• Web Site: https://www.jstage.jst.go.jp/article/circj/77/4/77_CJ-12-1043/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014027916
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可