Impact of Septal Curvature on Regional Strain in Patients With Hypertrophic Cardiomyopathy
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- Inoue Katsuji
- Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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- Okayama Hideki
- Department of Cardiology, Ehime Prefectural Central Hospital
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- Nishimura Kazuhisa
- Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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- Nagai Takayuki
- Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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- Suzuki Jun
- Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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- Ogimoto Akiyoshi
- Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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- Saito Makoto
- Department of Cardiology, Kitaishikai Hospital
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- Yoshii Toyofumi
- Department of Cardiology, Kitaishikai Hospital
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- Hiasa Go
- Department of Cardiology, Kitaishikai Hospital
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- Sumimoto Takumi
- Department of Cardiology, Kitaishikai Hospital
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- Funada Jun-ichi
- Department of Cardiology, Ehime National Hospital
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- Shigematsu Yuji
- Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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- Hamada Mareomi
- Department of Cardiology, Uwajima City Hospital
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- Higaki Jitsuo
- Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine
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Background: The interventricular septum in hypertrophic cardiomyopathy (HC) has a unique shape, which is characterized by the convex curvature toward the left ventricle (LV). The aim of this study was to examine the relationship between curvature of the LV wall and regional myocardial strain. Methods and Results: Fifty-six patients with HC (mean age, 55±12 years) and 20 age- and sex-matched control subjects (mean age, 56±8 years) were enrolled. The curvature index (1/radius) was measured by drawing along the endocardial surface from the apical 4-chamber and short axis views. Peak systolic strain was calculated in the septal and lateral walls using 2-D speckle tracking echocardiography. The septal curvature index and septal longitudinal strain were significantly lower in the HC group than in the control group. A multivariate model using the HC patient data showed that the septal curvature index and septal thickness were the independent determinants of septal longitudinal strain (septal curvature index: β=–0.421, P<0.001; septal thickness: β=0.401, P=0.002). In addition, global longitudinal strain and E/e’ were worse in the lower septal curvature index group compared with the higher group. Conclusions: Septal longitudinal strain is associated with the degree of septal curvature. This indicates a possible link between LV wall configuration and regional myocardial function. (Circ J 2013; 77: 1040–1045)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 77 (4), 1040-1045, 2013
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205103412608
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- NII論文ID
- 10031139009
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BC3s3jslClug%3D%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 23258249
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可