Flow-Mediated Vasodilation and Anatomical Variation of the Brachial Artery (Double Brachial Artery) in Healthy Subjects and Patients With Cardiovascular Disease

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Author(s)

    • FUJII Yuichi
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • TERAGAWA Hiroki
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • SOGA Junko
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • IDEI Naomi
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • FUJIMURA Noritaka
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • MARUHASHI Tatsuya
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • MIKAMI Shinsuke
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • IWAMOTO Yumiko
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • HIDAKA Takayuki
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • KIHARA Yasuki
    • Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences
    • CHAYAMA Kazuaki
    • Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences
    • NOMA Kensuke
    • Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University
    • NAKASHIMA Ayumu
    • Division of Regeneration and Medicine, Hiroshima University Hospital
    • HIGASHI Yukihito
    • Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

Abstract

<b><i>Background:</i></b> The purpose of this study was to evaluate the effect of anatomical variation of the brachial artery on flow-mediated vasodilation (FMD) in healthy subjects and patients with cardiovascular disease (CVD). <b><i>Methods and Results:</i></b> There was no significant difference in the prevalence of double brachial artery between healthy subjects (6.1%) and patients with CVD (6.5%). In healthy subjects, FMD was larger in a single brachial artery than in large and small vessels of a double brachial artery (7.2±3.4% vs. 4.7±3.3% and 4.5±2.5%, P<0.01, respectively). In patients with CVD, there were no significant differences in FMD among a single brachial artery, large vessel of a double brachial artery and small vessel of a double brachial artery (3.3±1.4%, 3.1±2.3% and 3.6±2.1%). FMD in a single brachial artery was smaller in patients with CVD than in healthy subjects. There were no significant differences in FMD in the large vessel of a double brachial artery between the 2 groups or in the small vessel of a double brachial artery between the 2 groups. Nitroglycerine-induced vasodilation was similar in all arteries in healthy subjects and patients with CVD. <b><i>Conclusions:</i></b> When measuring FMD, the existence of a double brachial artery should be checked. FMD measured in a double brachial artery may be underestimated in healthy subjects.  (Circ J 2013; 77: 1073–1080)<br>

Journal

  • Circulation Journal

    Circulation Journal 77(4), 1073-1080, 2013-03-25

    The Japanese Circulation Society

References:  31

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